I recognition of hepatitis C virus RNA

S. Thomas and G. Martin for technical assistance. This work was supported by funds from the State of Washington， A. Miyawaki， T. Taniguchi。

C. Rice。

R. Hirai for technical consultation， G. Sen。

S. Akira for reagents， We thank T. Fujita for discussions， and produced， and J. Briley， purified and tested recombinant RIG-I proteins. M.G. directed the research. All authors participated in study design and manuscript preparation. T.S. wrote the manuscript. ， National Institutes of Health grants R01AI060389， R01DA021353。

and by a gift from Mr. and Mrs. R. Batcheldor. Author Contributions T.S. conducted RNA binding studies and RIG-I signalling analyses. T.S. and D.M.O. conducted in vivo studies. F.J. and J.M. developed the RIG-I protein-expression system， U19AI40035 (Project 4) and the Burroughs-Wellcome Fund。

S. Lemon。

and S. Horner for manuscript review. We thank T. Fujita，。