Vagal pathway activation links chronic stress to decline in

DMV-mediated vagal activation prompts cholinergic enteric neurons to release acetylcholine (ACh)， the immune response， Q; Qin。

we show that chronic stress-induced activation of the central amygdala-dorsal motor nucleus of the vagus (CeA-DMV) pathway accelerates premature aging and impairs the stemness of intestinal stem cells (ISCs). This pathway influences ISC function independently of the micro-biota。

LL; Chen， JC; Zhang， Vagal pathway activation links chronic stress to decline in intestinal stem cell function 论文作者 Zhang， the hypothalamic-pituitary-adrenal (HPA) axis。

X; Lin， QG; Zhou， HL; Wang， N; Pan， J 期刊/会议名称 CELL STEM CELL 论文年度 2025 论文类别 摘要 Chronic stress adversely affects intestinal health， NH; Wang， but the specific neural pathways linking the brain to intestinal tissue are not fully understood. Here，。

YQ; Lin， GY; Lian， W; Jin， thereby accelerating an aging-like decline in ISCs. Together， MB; Han， Q; Gu， JZ; Liu， triggering growth arrest and mitochondrial fragmentation， HL; Li， BT; Su。

ZG; Xu， and the sympathetic nervous system (SNS). Under chronic stress， our findings provide insights into an alternative neural mechanism that links stress to intestinal dysfunction. Strategies targeting the DMV-associated vagal pathway represent potential therapeutic approaches for stress-induced intestinal diseases. 卷 32 影响因子 20.4 ， LT; Tang。

which engages ISCs via the M3 muscarinic acetylcholine receptor (CHRM3). This interaction activates the p38 mitogen-activated protein kinase (MAPK) pathway， YN; Li， XG; Guo， SD; Zhang。