REVERT : REVErsing airway Remodelling with...

Comparaison on CT-scan in the change in mean percentage bronchial wall area (%WA) at the B1 and B8 bronchi， generations 3， 4 and 5 between baseline and 6 months Comparaison on CT-scan in the change in mean percentage bronchial wall area (%WA) at the B1 and B8 bronchi， generations 3， generations 3， 4 and 5 between baseline and 6 months Comparaison on CT-scan in the average percentage bronchial wall area(%WA) corrected by body surface area(BSA) at the B1 and B8 bronchi， 4 and 5 between baseline and 6 months Change in the expiratory to inspiration ratio of mean lung density (MLDe/i) at Baseline， 4 and 5 between baseline and 6 months Comparaison on CT-scan in the average percentage bronchia wall thickness index (%WT) at the B1 and B8 bronchi。

generations 3， 4 and 5 between baseline and 6 months Comparaison on CT-scan the change in ratio wall area (WA) / lumen area(LM) at the B1 and B8 bronchi， 4 and 5 between baseline and 6 months 次要结局 Comparaison on CT-scan the change in mean %WA between arms between baseline and 12 months Comparaison on CT-scan in the average percentage bronchia wall thickness index (%WT) at the B1 and B8 bronchi， 4 and 5 between baseline and 6 months Comparaison on CT-scan the change in lumen circularity at the B1 and B8 bronchi， generations 3。

6 months and 12 months Quantitative computed tomography measurements to evaluate airflow obstruction at Baseline， 4 and 5 between baseline and 6 months Comparaison on CT-scan in the average percentage bronchial wall thickness (%WT) corrected by body surface area (BSA) at the B1 and B8 bronchi， 4 and 5 between baseline and 6 months Change in total lung capacity between Baseline and 6 months Comparaison on CT-scan the change in lumen area at the B1 and B8 bronchi。

generations 3， generations 3， 4 and 5 between baseline and 6 months Comparaison on CT-scan the change in lumen diameter at the B1 and B8 bronchi， Cough and Sputum Scale (BCSS) between Baseline and 12 months Change in Sino Nasal Outcome Test 22 between Baseline and 6 months Change in Sino Nasal Outcome Test 22 between Baseline and 12 months Change in St George Respiratory Questionnaire (SGRQ) between Baseline and 6 months Change in St George Respiratory Questionnaire (SGRQ) between Baseline and 12 months Change in ECRHS III Main Questionnaire between Baseline and 6 months Change in ECRHS III Main Questionnaire between Baseline and 12 months Changes in serum Club cell secretory protein (CCSP) between baseline and 6 months Changes in serum Club cell secretory protein (CCSP) between baseline and 12 months Number of adverse event between arms between baseline and 6 months 。

4 and 5 between baseline and 12 months Comparaison on CT-scan the change in wall area at the B1 and B8 bronchi。

generations 3， generations 3， Cough and Sputum Scale (BCSS) between Baseline and 6 months Change in Breathlessness， 6 months and 12 months Change in Total small Airway Count (TAC) between Baseline and 6 months Change in Total small Airway Count (TAC) between Baseline and 12 months Change in Lund Mackay score between Baseline and 6 months Change in Lund Mackay score between Baseline and 12 months Change in Presence/absence of nasal polyposis between Baseline and 6 months Change in Presence/absence of nasal polyposis between Baseline and 12 months Change in Annualized exacerbation rates between Baseline and 12 months Change in Days alive and not exacerbating between Baseline and 12 months Change in Days alive and not hospitalized between Baseline and 12 months Change in forced expiratory volume in 1 second between Baseline and 6 months Change in forced expiratory volume in 1 second between Baseline and 12 months Change in forced vital capacity between Baseline and 6 months Change in forced vital capacity between Baseline and 12 months Change in forced expiratory volume in 1 second / forced vital capacity Ratio between Baseline and 6 months Change in forced expiratory volume in 1 second / forced vital capacity Ratio between Baseline and 12 months Change in total lung capacity between Baseline and 12 months Change in residual volume between Baseline and 6 months Change in residual volume between Baseline and 12 months Change in total lung capacity (TLC)/ residual volume(RV) ratio between Baseline and 6 months Change in total lung capacity (TLC)/ residual volume(RV) ratio between Baseline and 12 months Change in mean ACQ (Asthma Control Questionnaire)-6 score between Baseline and 6 months Change in mean ACQ (Asthma Control Questionnaire)-6 score between Baseline and 12 months Change in Breathlessness， generations 3， generations 3，。