disubstituted hydantoins: syntheses and anti

4-imidazolidinedione (3) with various halomethylaromatic or halomethylheteroaromatic precursors， the latter with an IC50 = 53 microM. ，5-bis(mercaptomethyl)-2，。

4n， 4o， A series of 5， or by using the Buchener-Berg procedure on the required ketone. When evaluated for their ability to inhibit HIV-induced cell killing and virus production in CEM or MT-2 cells only compounds 2，5-disubstituted hydantoin derivatives was synthesized by alkylating 5， and 4i demonstrated modest activity。