Rare Earth Amide-Catalyzed Direct Thioesterification of Alde

Email: chj nbt.edu.cn， Org. Lett.， 8672-8676. DOI: 10.1021/acs.orglett.3c03497 see article for more reactions Abstract Y[N(SiMe3)2]3(-Cl)Li(THF)3 catalyzes a direct thioesterification of aldehydes with thiols under room temperature and solvent-free conditions， whereas this new method circumvents these issues. The study highlights the superior performance of yttrium/lithium amide catalysts， without using any additive or external oxidant. This method provides a straightforward and atom-efficient approach for the thioester synthesis. see article for more examples proposed mechanism Details The document discusses the development of a novel method for the direct thioesterification of aldehydes with thiols using rare earth/lithium amide catalysts， Yingming Yao* *NingboTech University， solvent-free conditions at room temperature without requiring additives or external oxidants， Sajid Imran， Xuehua Zhu， X. Zhu， 2023 ， Jue Chen*， S. Imran， D. Yuan， making it an efficient and straightforward approach for synthesizing thioesters. Traditional methods for thioester synthesis often involve carboxylic acids and produce significant waste， Organic Chemistry Portal Abstracts Rare Earth Amide-Catalyzed Direct Thioesterification of Aldehydes with Thiols under Mild ConditionsNadia Ismaeel， Y. Yao， Ningbo 315100; Soochow University， J. Chen。

yuandan suda.edu.cn， achieving high yields in short reaction times. The scope of the reaction includes various substituted benzaldehydes and thiols， 25， yaoym suda.edu.cn N. Ismaeel，Tishchenko reaction ， demonstrating broad substrate compatibility and functional group tolerance. Mechanistic investigations suggest the formation of rare earth thiolate intermediates and the role of aldehyde as both reactant and oxidant. This method represents a significant advancement in thioester synthesis， People's Republic of China， Suzhou 215123， Dan Yuan*。

specifically RE[N(SiMe3)2]3(-Cl)Li(THF)3. This method operates under mild， offering a more sustainable and efficient alternative to existing methods. Further research is ongoing to explore rare earth-based catalysts for other atom-economic transformations. Key Words thioesters，。