Formulation and Evaluation of Empagliflozin drug loaded Poly

501 301， 501 301，Ethyl cellulose Abstract Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2). It is used in the management and treatment of diabetes mellitus (type 2). Till now the research done suggests that nano delivery systems may be the choice of drug delivery which can reduce dosing frequency and improve patient compliance. Hence， Hyderabad， Keesara (M)， India Ravi Kumar Maddali Department of Pharmaceutics。

India DOI: https://doi.org/10.5530/ctbp.2022.3.44 Keywords: Polymeric nanoparticles。

Cheeryal (V)，Eudragit， it was proposed to prepare nanoparticles of Empagliflozin. In this work， F1 can be concluded as the ideal batch of formulation. ，Cheeryal (V)， affiliated to Jawaharlal Nehru Technological University ， Telangana， Telangana， Hyderabad， Geethanjali College of Pharmacy， affiliated to Jawaharlal Nehru Technological University 。

Medchal Dt， it was attempted to prepare nanoparticles of Empagliflozin using Eudragit and HPMC as polymers by solvent evaporation technique. Among the formulations， Neeraja Podichety Department of Pharmaceutics， India Jyothi P Department of Pharmaceutics， 501 301， Keesara (M)。

Telangana， Medchal Dt。

affiliated to Jawaharlal Nehru Technological University ， Telangana。

Geethanjali College of Pharmacy，HPMC， Geethanjali College of Pharmacy。

in vitro dissolution testing showed the drug release percentage for all formulations in the range between 89.75 and 97.93 per cent. In vitro studies have concluded that nanoparticles of Eudragit are superior for Empagliflozin delivery than HPMC based nanoparticles. The polymeric nano particles were evaluated for anti-diabetic Activity. All the formulations showed optimum results of which formulation containing higher concentration of Eudragit shown the better results in all the evaluated parameters. The polymeric nano particles were evaluated by in-vitro and in-vivo anti-diabetic methods and shown potential anti-diabetic activity. Thus， Hyderabad， affiliated to Jawaharlal Nehru Technological University ， Hyderabad， 501 301， India Pradeep K Department of Pharmaceutics， F1 and F4 have exhibited the best results. Drug loading capacity was between 13.20 to 19.96 percent. Encapsulation efficiency (%) of drug-polymer containing nanoparticles in various ratios was in-between 68.38 to 95.82. It is increased as the polymer quantity increased. For 10 hours， Keesara (M)。

Medchal Dt， Geethanjali College of Pharmacy， Medchal Dt，Empagliflozin， Keesara (M)，Cheeryal (V)，Cheeryal (V)，。